Human IL-1 alpha Recombinant Protein

Catalog Number:: RP1703H
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Homo sapiens (human), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee)

Human IL-1α (Interleukin-1 alpha) (catalog RP1703H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.0 kDa, 158 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human, pygmy chimpanzee, and chimpanzee. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-1α signaling and inflammatory responses (including regulation of immune activation, cytokine production, and inflammatory pathways); typical experimental uses include cell-culture stimulation and cytokine assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQ (158)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	18.0 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Human Interleukin-1 Alpha (IL-1α) is a pro-inflammatory cytokine belonging to the IL-1 family-which includes IL-1α, IL-1β, and the IL-1 receptor antagonist (IL-1Ra)-and plays a central role in initiating innate immune and sterile inflammatory responses. Unlike IL-1β, IL-1α is constitutively expressed in epithelial, endothelial, and other barrier tissues and functions as an intracellular alarmin that is rapidly released upon cell injury, necrosis, or cellular stress. Once released, IL-1α binds to the IL-1 receptor type 1 (IL-1R1), activating NF-κB and MAPK signaling pathways that drive leukocyte recruitment, endothelial activation, fever, and amplification of downstream pro-inflammatory cytokine cascades. IL-1α is critically involved in inflammatory skin diseases, atherosclerosis, rheumatoid arthritis, inflammatory bowel disease, cancer-associated inflammation, and sterile injury responses such as ischemia-reperfusion damage. While essential for host defense and tissue repair, dysregulated or excessive IL-1α signaling contributes to chronic inflammation and tissue pathology. As both a biomarker and therapeutic target, human IL-1α is central to research on inflammasome-independent inflammation, tumor microenvironment biology, and development of IL-1-targeted biologics aimed at modulating cytokine-driven disease.

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