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Feline IL-25 (IL-17E) Recombinant Protein
- Catalog Number:
- RP1706F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat)
- Feline IL-25 (IL-17E) (catalog RP1706F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.3 kDa, 151 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-25/IL-17E signaling and immune responses (including regulation of type 2 immunity, inflammation, and cytokine production); typical experimental uses include cell-culture stimulation and cytokine assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | IRIKKDCIHW SSCCPSKGQN PTHEWLTENT VLMTPPESAS LIHSLESCRA SEDGPLNSRS ISPWRYELDR DLNRLPQDLY HARCLCPHCV SLQTGSHMDP LGNSELLYHN QTVFYRRPCP GEQGTRDGYC LEQRLYRVSL ACVCVRPRVM A (151) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.3 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline interleukin-25 (IL-25), also known as IL-17E, is a member of the IL-17 cytokine family and functions as a key regulator of type 2 immune responses through signaling via the IL-17RA/IL-17RB receptor complex and downstream NF-κB and MAPK pathways. In cats, IL-25 is expected to promote Th2-associated cytokine production (including IL-4, IL-5, and IL-13), eosinophil recruitment, and mucosal immune activation, playing an important role in defense against parasitic infections while also contributing to allergic and inflammatory conditions. In feline health, IL-25 is particularly relevant in diseases characterized by type 2 immune polarization, such as feline asthma, allergic dermatitis, eosinophilic granuloma complex, and inflammatory bowel disease. Dysregulated IL-25 signaling may exacerbate airway hyperreactivity, skin inflammation, and gastrointestinal eosinophilia, mirroring its role in comparable human conditions including asthma, atopic dermatitis, chronic rhinosinusitis, and food allergy. Because cats naturally develop spontaneous allergic airway disease and chronic inflammatory disorders within an intact immune system, feline IL-25 serves as both a potential biomarker and therapeutic target in veterinary medicine, as well as a valuable comparative model for studying type 2-driven inflammatory diseases across species.
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