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Bovine CXCL4 (PF-4) Recombinant Protein
- Catalog Number:
- RP1713B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos indicus (zebu), Bos taurus (cattle)
- Bovine CXCL4 (Platelet Factor 4, PF4) (catalog RP1713B) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~9.3 kDa, 86 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, American buffalo, and zebu. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL4/PF4 signaling and immune responses (including roles in platelet activation, inflammation, and chemotaxis); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QESSFPATFV PLPADSEGGE SEDLQCVCLK TTSGINPRHI SSLEVIGAGL HCPSPQLIAT LKTGRKICLD QQNPLYKKII KRLLKS (86) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 9.3 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CXCL4 (C-X-C motif chemokine ligand 4), also known as Platelet Factor 4 (PF4), is a CXC chemokine primarily released from α-granules of activated platelets and belonging to the platelet chemokine subgroup of the CXC chemokine family. In cattle (Bos taurus), CXCL4 is produced mainly by platelets and megakaryocytes and is released during platelet activation, vascular injury, or inflammation. CXCL4 plays roles in regulating coagulation, modulating inflammatory responses, and influencing leukocyte recruitment, particularly affecting monocytes, neutrophils, and other immune cells. It can also interact with glycosaminoglycans on endothelial cells and platelets, helping regulate platelet aggregation, vascular repair, and immune cell signaling at sites of tissue damage. In bovine health, CXCL4 is involved in inflammatory and thrombotic processes, including those occurring during infection, tissue injury, and inflammatory diseases such as mastitis or systemic inflammatory responses, where platelet activation and immune cell recruitment contribute to host defense and tissue repair. Because platelet-derived chemokines influence both hemostasis and immune regulation, bovine CXCL4 is studied in veterinary immunology, inflammation research, and host-pathogen interaction studies to better understand platelet-immune system interactions and inflammatory signaling in cattle.
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