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Bovine CXCL1 (GRO alpha) Recombinant Protein
- Catalog Number:
- RP1715B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American Buffalo), Bos taurus (cattle)
- Bovine CXCL1 (GRO-α, Growth-Regulated Alpha Protein) (catalog RP1715B) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.0 kDa, 74 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle and American buffalo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL1/GRO-α signaling and immune-cell chemotaxis (including recruitment and activation of neutrophils during inflammatory responses); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | GAPVVNELRC QCLQTLQGIH LKNIQSVKVT TPGPHCDQTE VIASLKTGQE VCLNPTAPMV KKIIDKMLNK ASAN (74) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CXCL1 (C-X-C motif chemokine ligand 1), also known as GRO-α (growth-regulated oncogene alpha), is a proinflammatory chemokine belonging to the CXC chemokine family, which includes related chemokines such as CXCL2, CXCL3, and CXCL8 (IL-8) that regulate neutrophil recruitment during inflammatory responses. In cattle (Bos taurus), CXCL1 is produced by macrophages, epithelial cells, endothelial cells, fibroblasts, and other immune or tissue cells in response to infection, inflammatory cytokines, or tissue injury. CXCL1 exerts its biological effects primarily through binding to the chemokine receptor CXCR2, promoting chemotaxis, activation, and migration of neutrophils to sites of infection or inflammation. In bovine health, CXCL1 plays an important role in innate immune defense, particularly during bacterial infections such as mastitis, where recruitment of neutrophils to the mammary gland is critical for pathogen clearance. CXCL1 is also involved in inflammatory responses associated with bovine respiratory disease and other infectious conditions. Because neutrophil-mediated host defense is essential for protecting cattle against bacterial pathogens, bovine CXCL1 is widely studied in veterinary immunology, mastitis research, and host-pathogen interaction studies, helping to improve understanding of inflammatory signaling and immune responses in livestock.
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