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Bovine CD27 (TNFRSF7) Recombinant Protein
- Catalog Number:
- RP1718B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos indicus (Zebu), Bos taurus (cattle)
- Bovine CD27 (TNFRSF7) (catalog RP1718B) is a yeast-derived receptor protein supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.7 kDa, 160 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle and zebu. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CD27 signaling and immune responses (including regulation of T-cell activation, survival, and differentiation as part of TNF receptor superfamily pathways); typical experimental uses include cell-culture stimulation and receptor-binding assays, immune signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | TPGPKSCPEK HYWAQGGWCC QMCEPGTFLV KDCEQHREAA QCNPCTPGVS FMPDHHSRPH CESCRHCNSG LLIRNCTLTA NSECACPEGQ QCRDKDCMEC DGPAQAPGPH PQPSHLPYAE EIAESRTDRH TQTLANSRWL PAPTLSTHWS PQRSLCSANC (160) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.7 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CD27 is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily, which includes related receptors such as CD40, OX40 (CD134), 4-1BB (CD137), and CD30 that regulate lymphocyte activation and survival. In cattle (Bos taurus), CD27 is primarily expressed on T lymphocytes, memory B cells, and subsets of natural killer (NK) cells, where it functions as an important costimulatory receptor in adaptive immune responses. CD27 interacts with its ligand CD70 (TNFSF7) expressed on activated antigen-presenting cells and lymphocytes, triggering intracellular signaling pathways including NF-κB and MAPK that promote lymphocyte activation, proliferation, survival, and differentiation into memory cells. In bovine immunology, CD27 plays a key role in T cell costimulation and the development and maintenance of memory lymphocyte populations, contributing to effective immune responses against viral, bacterial, and parasitic pathogens affecting cattle. Because the CD27-CD70 signaling pathway is critical for adaptive immune regulation and long-term immune memory, bovine CD27 is studied in veterinary immunology, vaccine development, and host-pathogen interaction research, particularly for improving protective immunity and vaccine responses in cattle.
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