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Rat CD27 (TNFRSF7) Recombinant Protein
- Catalog Number:
- RP1719R
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Rattus norvegicus (Norway rat), Rattus rattus (black rat)
- Rat CD27 (TNFRSF7) (catalog RP1719R) is a yeast-derived receptor protein supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~11.5 kDa, 104 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to Norway rat and black rat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CD27 signaling and immune responses (including regulation of T-cell activation, survival, and differentiation within TNF receptor superfamily pathways); typical experimental uses include cell-culture stimulation and receptor-binding assays, immune signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | TPAPNNCPDR HYWIGAGLCC QMCGPGTFLV KHCDQDRAAA QCDPCIPGTS FSPDYHTRPH CESCRHCNSG FLIRNCTVTA NAECTCSKGW QCRDQECTEC DPPL (104) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 11.5 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Rat CD27 is a type I transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily, which also includes receptors such as CD40, OX40 (CD134), 4-1BB (CD137), and CD30 that regulate lymphocyte activation, survival, and differentiation. In rats (Rattus norvegicus), CD27 is primarily expressed on T lymphocytes, subsets of B cells, and natural killer (NK) cells, where it functions as an important costimulatory receptor in adaptive immune responses. CD27 interacts with its ligand CD70 (TNFSF7), which is expressed on activated antigen-presenting cells and lymphocytes, triggering intracellular signaling pathways such as NF-κB and MAPK that promote lymphocyte activation, proliferation, survival, and differentiation into effector and memory cells. In rat immunology, CD27 plays a key role in T cell costimulation, regulation of immune activation, and formation of long-lived immune memory, contributing to host defense against viral, bacterial, and parasitic infections. Because rats are widely used as experimental models for immunology, autoimmune disease, and transplantation research, rat CD27 has been studied in models of immune regulation, inflammatory disease, and T-cell-mediated immunity, helping to clarify mechanisms of costimulatory signaling and adaptive immune responses relevant to both veterinary and human biomedical research.
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