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Bovine CCL1 Recombinant Protein
- Catalog Number:
- RP1735B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo)
- Bovine CCL1 (I-309, T-cell Activation Protein-3) (catalog RP1735B) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.0 kDa, 70 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, zebu, wild yak, and water buffalo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL1/I-309 signaling and immune responses (including regulation of T-cell activation and chemotaxis during inflammatory responses); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | KSMHVPSSNC CFRTVKGKIS PKKIQCYKNI SSTCSYNDRL IFKLTGGLQS CVLQKDLWVQ AYLKRINLCQ (70) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CCL1 (C-C motif chemokine ligand 1), also known as I-309, is a member of the CC chemokine family that plays a role in regulating leukocyte trafficking and immune responses in cattle (Bos taurus). CCL1 is produced primarily by activated T lymphocytes, monocytes, macrophages, and endothelial cells in response to inflammatory stimuli, and it functions mainly through the CCR8 receptor to recruit monocytes, T cells, and other immune effector cells to sites of inflammation. In healthy cattle, basal CCL1 expression is typically low, but levels can increase during infection, tissue injury, or immune activation. Elevated CCL1 expression has been associated with inflammatory and infectious conditions such as mastitis, respiratory disease, enteric infections, and parasitic challenges, reflecting its role in coordinating cellular immune responses. In veterinary and agricultural research, bovine CCL1 serves as a biomarker of immune activation and leukocyte recruitment, providing insight into host-pathogen interactions, vaccine responses, and inflammatory regulation in cattle.
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