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Rat CCL2 (MCP-1) Recombinant Protein
- Catalog Number:
- RP1746R
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Rattus norvegicus (Norway rat)
- Rat CCL2 (MCP-1, Monocyte Chemoattractant Protein-1) (catalog RP1746R) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~14.1 kDa, 125 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to Norway rat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL2/MCP-1 signaling and immune responses (including recruitment and activation of monocytes, macrophages, and other leukocytes during inflammatory processes); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN (125) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 14.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Rat CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that plays a central role in recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in rats (Rattus norvegicus). CCL2 signals primarily through the CCR2 receptor, activating intracellular pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection, tissue injury, or inflammation. In rat research, CCL2 is widely studied in experimental models of neuroinflammation, cardiovascular disease, metabolic disorders, and kidney injury, where monocyte and macrophage infiltration contributes to tissue remodeling and disease progression. Rat CCL2 is also important in neuropathic pain and central nervous system injury models, where it mediates recruitment of immune cells to the brain and spinal cord and influences neuroimmune signaling. While CCL2-driven immune cell trafficking supports host defense and tissue repair, excessive or sustained expression can promote chronic inflammation and tissue damage. Because rats are widely used in pharmacology, neuroscience, and cardiovascular research, characterization of rat CCL2 supports investigations into chemokine-mediated immune regulation, inflammatory disease mechanisms, and development of targeted anti-inflammatory therapies relevant to human disease.
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