Egyptian Rousette Bat CXCL15 Recombinant Protein

Catalog Number:
RP1762BT
Availability:
In stock
Application:
Cell Culture, Control, ELISA, ELISpot Control, Western Blot Control
100% Homology:
Rousettus aegyptiacus (Egyptian rousette)
  • Bat CXCL15 (Lungkine) (catalog RP1762BT) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.0 kDa, 69 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to Egyptian rousette. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL15/lungkine signaling and immune responses (including roles in neutrophil recruitment and mucosal immunity in the lung); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
Amino Acid SequenceQELRCQCVQT YSNFIHPIFF ENIQLIPEGP HCRRKEVIVT LRNGKLVCLD PEAKWVMTII KKIKDSAAH (69)
EndotoxinNaturally endotoxin-free
FormLyophilized
Storage Conditions-20°C
Molecular Weight8.0 kDa
Purity>98% as visualized by SDS-PAGE analysis.
Expression SystemYeast
FormLyophilized
Country Of OriginUSA
Egyptian Rousette Bat (Rousettus aegyptiacus) CXCL15 (C-X-C motif chemokine ligand 15), also known in some species as lungkine, is a CXC chemokine involved primarily in mucosal immunity and neutrophil recruitment in the respiratory tract. CXCL15 belongs to the CXC chemokine family, which includes chemokines such as CXCL1, CXCL2, and CXCL8 (IL-8) that regulate neutrophil trafficking during inflammatory and innate immune responses. In Egyptian Rousette bats, CXCL15 is likely expressed predominantly by respiratory epithelial cells and other lung-associated tissues, where it contributes to local immune surveillance and recruitment of neutrophils to airway surfaces during infection or inflammation. Egyptian Rousette bats are natural reservoirs for Marburg virus, and chemokines such as CXCL15 may help coordinate early innate immune responses in the respiratory tract, facilitating immune cell recruitment while maintaining controlled inflammatory responses. Studying CXCL15 in this species supports research into bat respiratory immunity and host–pathogen interactions, helping to elucidate mechanisms that allow bats to tolerate viral infections with limited immunopathology, which is important for understanding zoonotic virus ecology and bat immune system adaptations.

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