Ovine CCL28 (C-C motif chemokine ligand 28, also known as MEC – mucosae-associated epithelial chemokine) is a mucosal chemokine that plays an important role in immune cell trafficking and mucosal immune defense in sheep (Ovis aries). CCL28 primarily signals through the CCR10 receptor and, to a lesser extent, CCR3, promoting chemotaxis of IgA-secreting plasma cells, memory T cells, and certain dendritic cell populations to mucosal tissues. In sheep, CCL28 is predominantly produced by epithelial cells at mucosal surfaces, including the intestinal tract, respiratory epithelium, mammary gland, and salivary glands, where it helps recruit IgA-producing plasma cells and supports secretory IgA–mediated immunity at barrier tissues. CCL28-mediated immune cell trafficking is particularly important for defense against gastrointestinal parasites, bacterial enteric infections, and respiratory pathogens, which commonly affect small ruminants. In addition, CCL28 plays a role in the mammary gland during lactation, helping direct IgA-producing cells to mammary tissue and supporting passive immune protection for newborn lambs through colostrum and milk. Proper regulation of CCL28 supports mucosal immune surveillance and pathogen defense, while dysregulation may contribute to mucosal inflammation. Characterization of ovine CCL28 supports research into mucosal immunity, host–pathogen interactions, and vaccine strategies aimed at improving disease resistance and health in sheep production systems.