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Canine CXCL7 Recombinant Protein
- Catalog Number:
- RP1766D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog)
- Canine CXCL7 (NAP-2, Neutrophil-Activating Peptide 2) (catalog RP1766D) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.9 kDa, 80 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog and dingo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL7/NAP-2 signaling and immune responses (including activation and recruitment of neutrophils during inflammatory processes); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | TALASSTKGQ TKRNLAKGKE ESLDSDLYAE LRCMCIKTTS GIHPKNIQSL EVIGKGTHCN QVEVIATLKD GRKICLDPDA PRIKKIVQKK LAGDESAD (98) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CXCL7 (C-X-C motif chemokine ligand 7), also known as NAP-2 (neutrophil-activating peptide 2) or PPBP (pro-platelet basic protein), is a platelet-derived chemokine belonging to the ELR⁺ CXC chemokine family, which also includes CXCL1, CXCL2, CXCL3, and CXCL5 that regulate neutrophil recruitment during inflammatory responses. In cattle (Bos taurus), CXCL7 is produced primarily by platelets and megakaryocytes and is released upon platelet activation during vascular injury, inflammation, or infection. CXCL7 signals mainly through the chemokine receptor CXCR2, expressed on neutrophils and other innate immune cells, promoting neutrophil chemotaxis, activation, and migration to sites of tissue damage or infection. In bovine health, CXCL7 contributes to the interaction between the coagulation system and immune responses, particularly in inflammatory conditions affecting tissues such as the mammary gland and respiratory tract, where platelet activation and neutrophil recruitment play roles in host defense during diseases such as mastitis and respiratory infections. Because platelet-derived chemokines influence both hemostasis and inflammatory signaling, bovine CXCL7 is studied in veterinary immunology, inflammation research, and host-pathogen interaction studies to better understand platelet-mediated immune regulation and neutrophil-driven inflammatory responses in cattle.
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