Swine CXCL7 (C-X-C motif chemokine ligand 7), also known as NAP-2 (neutrophil-activating peptide 2) or PPBP (pro-platelet basic protein), is a platelet-derived chemokine belonging to the ELR⁺ CXC chemokine family, which includes CXCL1, CXCL2, CXCL3, and CXCL5 that regulate neutrophil recruitment during inflammatory responses. In pigs (Sus scrofa), CXCL7 is produced primarily by platelets and megakaryocytes and is released during platelet activation following vascular injury, infection, or inflammatory signaling. CXCL7 signals mainly through the chemokine receptor CXCR2, which is expressed on neutrophils and other innate immune cells, promoting chemotaxis, activation, and migration of neutrophils to sites of tissue damage or infection. In swine health, CXCL7 contributes to the interaction between coagulation and immune responses, particularly in inflammatory conditions affecting the vascular system and respiratory tract, where platelet activation and neutrophil recruitment help coordinate host defense and tissue repair. Because pigs share important physiological and cardiovascular similarities with humans, swine are widely used as translational animal models for thrombosis and cardiovascular disease, and CXCL7-mediated platelet–leukocyte signaling has been studied in porcine models of atherosclerosis and vascular injury to better understand platelet-driven inflammation and evaluate antithrombotic and anti-inflammatory therapies relevant to human medicine.