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Swine CXCL7 Recombinant Protein
- Catalog Number:
- RP1767S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine CXCL7 (NAP-2, Neutrophil-Activating Peptide 2) (catalog RP1767S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.6 kDa, 80 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL7/NAP-2 signaling and immune responses (including activation and recruitment of neutrophils during inflammatory processes); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | AAKIEGRMAH VELRCLCLNT VSGIHPSNIQ SLEVIRAGAH CAKVEVIATL KNDKKICLDP EAPRIKKIVQ KIMEDGGSAA (80) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine CXCL7 (C-X-C motif chemokine ligand 7), also known as NAP-2 (neutrophil-activating peptide 2) or PPBP (pro-platelet basic protein), is a platelet-derived chemokine belonging to the ELR⁺ CXC chemokine family, which includes CXCL1, CXCL2, CXCL3, and CXCL5 that regulate neutrophil recruitment during inflammatory responses. In pigs (Sus scrofa), CXCL7 is produced primarily by platelets and megakaryocytes and is released during platelet activation following vascular injury, infection, or inflammatory signaling. CXCL7 signals mainly through the chemokine receptor CXCR2, which is expressed on neutrophils and other innate immune cells, promoting chemotaxis, activation, and migration of neutrophils to sites of tissue damage or infection. In swine health, CXCL7 contributes to the interaction between coagulation and immune responses, particularly in inflammatory conditions affecting the vascular system and respiratory tract, where platelet activation and neutrophil recruitment help coordinate host defense and tissue repair. Because pigs share important physiological and cardiovascular similarities with humans, swine are widely used as translational animal models for thrombosis and cardiovascular disease, and CXCL7-mediated platelet-leukocyte signaling has been studied in porcine models of atherosclerosis and vascular injury to better understand platelet-driven inflammation and evaluate antithrombotic and anti-inflammatory therapies relevant to human medicine.
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