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Guinea Pig IFN alpha 17 Recombinant Protein
- Catalog Number:
- RP1785GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (Domestic guinea pig)
- Guinea Pig IFN-α17 (Interferon alpha 17) (catalog RP1785GP) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.9 kDa, 164 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IFN-α signaling and immune responses (including regulation of antiviral defense, innate immunity, and cytokine-mediated pathways); typical experimental uses include cell-culture stimulation and antiviral assays, cytokine signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | CTLPQTHSQG NTRALILLEQ MRRISPFSCL KHRQDFGLAQ LDFEGKQVQK AQALSILHEM TRQTFNLFIS EDSSAAWNKS LLHSFCTGLH QQLNDLEACL TQETGLEEPP LMHEDSRLVV RKYFHRIAVY LKEKSYSPCA WEVVRAQIVR SLSASEKLAR KMQD (164) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig Interferon-Alpha (IFN-α) is a type I interferon produced primarily by plasmacytoid dendritic cells and virus-infected cells in guinea pigs (Cavia porcellus), where it serves as a key mediator of early innate antiviral immunity. Upon binding to the type I interferon receptor complex (IFNAR1/IFNAR2), guinea pig IFN-α activates JAK/STAT signaling pathways, leading to induction of interferon-stimulated genes (ISGs) that inhibit viral replication, enhance antigen presentation, and promote activation of natural killer (NK) cells and adaptive immune responses. IFN-α plays an important role in guinea pig models of infectious diseases, including influenza virus, Lassa virus, Ebola virus (adapted strains), cytomegalovirus, and other viral pathogens, where interferon responses influence viral control, inflammation, and disease outcome. Because guinea pigs are widely used as translational models for respiratory infections and viral hemorrhagic fevers, characterization of IFN-α is essential for understanding antiviral defense mechanisms, immune-mediated pathology, vaccine efficacy, and antiviral therapeutic strategies. As both a biomarker and functional regulator of host-virus interactions, guinea pig IFN-α supports comparative immunology research and preclinical evaluation of countermeasures relevant to human infectious diseases.
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