Ferret CCL16 (C-C motif chemokine ligand 16), also known as liver-expressed chemokine (LEC) or HCC-4, is a member of the CC chemokine family involved in leukocyte recruitment and immune regulation in ferrets (Mustela putorius furo). CCL16 is primarily expressed in the liver and is produced by hepatocytes, monocytes, macrophages, and certain epithelial and stromal cells, particularly in response to inflammatory cytokines and immune stimulation. It functions mainly through chemokine receptors such as CCR1, CCR2, and CCR5 to promote chemotaxis and activation of monocytes, lymphocytes, and other immune effector cells. In healthy ferrets, basal circulating levels are expected to be low to moderate, contributing to immune surveillance and hepatic immune homeostasis; however, expression may increase during viral infection, systemic inflammation, respiratory disease, hepatic injury, or experimental immune challenge. In biomedical and translational research, ferret CCL16 is of interest in studies of influenza, SARS-CoV-2, and other respiratory pathogens, as well as in investigations of systemic inflammatory responses and immune cell trafficking. Characterization of ferret CCL16 provides insight into chemokine-mediated leukocyte recruitment and immune regulation in a widely used model of human infectious disease.