Human IFN beta Recombinant Protein

Catalog Number:: RP1788H
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Homo sapiens (human)

Human IFN-β (Interferon beta) (catalog RP1788H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~20.0 kDa, 166 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IFN-β signaling and immune responses (including regulation of antiviral defense, innate immunity, and cytokine-mediated pathways); typical experimental uses include cell-culture stimulation and antiviral assays, cytokine signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN (166)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	20.0 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Human Interferon-Beta (IFN-β) is a type I interferon produced primarily by virus-infected epithelial cells, fibroblasts, macrophages, and dendritic cells, where it functions as a critical early mediator of innate antiviral immunity. Upon recognition of viral RNA or DNA by pattern recognition receptors such as RIG-I, MDA5, and the cGAS-STING pathway, IFN-β is rapidly induced and signals through the type I interferon receptor complex (IFNAR1/IFNAR2), activating JAK/STAT pathways and driving expression of interferon-stimulated genes (ISGs) that inhibit viral replication, enhance antigen presentation, promote natural killer (NK) cell cytotoxicity, and shape adaptive immune responses. IFN-β plays a central role in defense against viral infections including influenza, hepatitis viruses, herpesviruses, SARS-CoV-2, and other emerging pathogens, with impaired or delayed IFN-β responses associated with severe disease outcomes. Conversely, chronic or dysregulated IFN-β signaling contributes to autoimmune and inflammatory conditions such as systemic lupus erythematosus and type I interferonopathies. Clinically, recombinant IFN-β is an established therapy for relapsing-remitting multiple sclerosis due to its immunomodulatory properties. As both a biomarker and therapeutic agent, human IFN-β is central to research on antiviral defense, immune dysregulation, neuroinflammation, and development of interferon-based or interferon-modulating treatments.

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