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Rat Erythropoietin (EPO) (Yeast-derived Recombinant Protein) - 25 micrograms

RP1805R-025
$300.00
In Stock
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Bulk quantities of Rat EPO protein are available.
Please contact us for pricing.

Rat EPO Specifications

Molecular Weight (calculated) - 18.5kDa

Amino Acid Sequence - APPRLICDSR VLERYILEAK EAENVTMGCA EGPRLSENIT VPDTKVNFYA WKRMKVEEQA VEVWQGLSLL SEAILQAQAL QANSSQPPES LQLHIDKAIS GLRSLTSLLR VLGAQKELMS PPDATQAAPL RTLTADTFCK LFRVYSNFLR GKLKLYTGEA CRRGDR (166)

Gene ID - 24335

Homology Across Species
Rattus norvegicus (Norway rat) EPO- 100%
Rattus rattus (black rat) EPO- 100%
More - https://blast.ncbi.nlm.nih.gov/

Endotoxin - Naturally endotoxin-free

Applications

Cell Culture, ELISA Standard, Western Blot Control

Erythropoietin Background

Erythropoietin (EPO) is an essential hormone for red blood cell production. Without it, definitive erythropoiesis does not take place. Erythropoietin has its primary effect on red blood cell progenitors and precursors by promoting their survival through protecting these cells from apoptosis. It is the primary erythropoietic factor that cooperates with various other growth factors (e.g., IL-3, IL-6, glucocorticoids, and SCF) involved in the development of erythroid lineage from multipotent progenitors. Erythropoietin has a range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis, and inducing proliferation of smooth muscle fibers. It can increase iron absorption by suppressing the hormone hepcidin. EPO is highly glycosylated, with half-life in blood around five hours. The half-life of EPO may vary between endogenous and various recombinant versions. Additional glycosylation or other alterations of EPO via recombinant technology have led to increased stability in blood. EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates a JAK2 signaling cascade. Erythropoietin receptor expression is found in a number of tissues, such as bone marrow and peripheral/central nervous tissue. In the bloodstream, red cells themselves do not express erythropoietin receptor, so cannot respond to EPO. However, indirect dependence of red cell longevity in the blood on plasma erythropoietin levels has been reported, a process termed neocytolysis.

Alternate Names - EPO, EP, MVCD2, erythropoietin, Erythropoietin, ECYT5, DBAL

Catalog No.:
RP1805R-025
Quantity:
25 ug
Source:
The Rat EPO recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Rat EPO recombinant protein has a predicted molecular weight of 18.5 kDa.
Protein Sequence:

APPRLICDSR VLERYILEAK EAENVTMGCA EGPRLSENIT VPDTKVNFYA WKRMKVEEQA VEVWQGLSLL SEAILQAQAL QANSSQPPES LQLHIDKAIS GLRSLTSLLR VLGAQKELMS PPDATQAAPL RTLTADTFCK LFRVYSNFLR GKLKLYTGEA CRRGDR (166)

Alias:
EPO
Country of Origin:
USA
Applications:
The Rat EPO endotoxin-free recombinant protein can be used in cell culture, as an EPO ELISA Standard, and as a Western Blot Control.
None at this time

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