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Human IL-36 alpha Recombinant Protein
- Catalog Number:
- RP1821H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human)
- Human IL-36α (Interleukin-36 alpha) (catalog RP1821H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.1 kDa, 153 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-36α signaling and immune responses (including regulation of inflammatory pathways, skin immunity, and cytokine-mediated immune responses); typical experimental uses include cell-culture stimulation and cytokine assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | KIDTPQQGSI QDINHRVWVL QDQTLIAVPR KDRMSPVTIA LISCRHVETL EKDRGNPIYL GLNGLNLCLM CAKVGDQPTL QLKEKDIMDL YNQPEPVKSF LFYHSQSGRN STFESVAFPG WFIAVSSEGG CPLILTQELG KANTTDFGLT MLF (153) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human Interleukin-36 Alpha (IL-36α) is a proinflammatory cytokine that plays an important role in regulating immune responses and inflammatory signaling in humans (Homo sapiens). IL-36α is a member of the IL-1 cytokine family and is produced primarily by epithelial cells, keratinocytes, and immune cells in response to infection, tissue damage, or inflammatory stimuli. Human IL-36α binds to the IL-36 receptor (IL-36R, also known as IL1RL2) together with the IL-1 receptor accessory protein (IL-1RAcP), activating intracellular signaling pathways such as NF-κB and MAPK that promote the expression of inflammatory mediators and recruitment of immune cells. Through these signaling pathways, IL-36α contributes to activation of dendritic cells, macrophages, and T lymphocytes and helps regulate communication between epithelial tissues and the immune system. In humans, IL-36α plays a significant role in inflammatory responses at barrier tissues such as the skin and mucosal surfaces and has been implicated in immune-mediated diseases including psoriasis and other inflammatory skin disorders. In cell culture, recombinant human IL-36α is commonly used to stimulate inflammatory signaling in epithelial and immune cells, induce cytokine and chemokine production, and investigate IL-36-mediated immune activation and epithelial-immune cell interactions in in vitro immunology and inflammation studies.
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