Ferret CCL26 (C-C motif chemokine ligand 26, also known as eotaxin-3) is a chemokine involved in recruitment of eosinophils and regulation of type 2 inflammatory responses in ferrets (Mustela putorius furo). CCL26 primarily signals through the CCR3 receptor, promoting chemotaxis of eosinophils, basophils, and Th2 lymphocytes to sites of infection, allergic inflammation, or tissue injury. In ferrets, CCL26 is likely produced by epithelial cells, macrophages, fibroblasts, and endothelial cells in response to Th2-associated cytokines such as IL-4 and IL-13, which stimulate eosinophil-associated immune pathways. CCL26-mediated signaling may contribute to immune responses in respiratory and mucosal tissues, where eosinophil recruitment participates in defense against parasites and modulation of inflammatory responses. In ferret research, this chemokine may be relevant in studies of respiratory disease models, including viral infections such as influenza and SARS-CoV-2, where regulation of inflammatory cell recruitment influences lung immune responses and tissue pathology. While CCL26-driven eosinophil migration supports protective immunity and tissue repair, excessive expression could contribute to airway inflammation or chronic inflammatory responses. Because ferrets are widely used as translational models for human respiratory disease and immunology, characterization of ferret CCL26 supports investigations into eosinophil-mediated inflammation, chemokine signaling, and immune regulation in respiratory and mucosal disease.