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Human CTLA-4 (Yeast-derived Recombinant Protein) - 25 micrograms

RP1844H-025
$300.00
In Stock
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Bulk quantities of Human CTLA-4 protein are available.
Please contact us for pricing.

Human CTLA-4 Specifications

Molecular Weight (calculated) - 13.5kDa

Amino Acid Sequence - KAMHVAQPAV VLASSRGIAS FVCEYASPGK ATEVRVTVLR QADSQVTEVC AATYMMGNEL TFLDDSICTG TSSGNQVNLT IQGLRAMDTG LYICKVELMY PPPYYLGIGN GTQIYVIDPE PCPDSD (126)

Gene ID - 1493

Homology Across Species
Homo sapiens (human) CTLA-4 – 100%
Pan paniscus (pygmy chimpanzee) CTLA-4 – 100%
Pan troglodytes (chimpanzee) CTLA-4 - 100%
Gorilla gorilla gorilla (western lowland gorilla) CTLA-4 – 100%
Pongo abelii (Sumatran orangutan) CTLA-4 – 99%
More - https://blast.ncbi.nlm.nih.gov/

Endotoxin - Naturally endotoxin-free

Applications

Cell Culture, ELISA Standard, Western Blot Control

CTLA-4 Background

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.

Alternate Names - CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4

Catalog No.:
RP1844H-025
Quantity:
25 ug
Source:
The Human CTLA-4 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Human CTLA-4 recombinant protein has a predicted molecular weight of 13.5 kDa.
Protein Sequence:

KAMHVAQPAV VLASSRGIAS FVCEYASPGK ATEVRVTVLR QADSQVTEVC AATYMMGNEL TFLDDSICTG TSSGNQVNLT IQGLRAMDTG LYICKVELMY PPPYYLGIGN GTQIYVIDPE PCPDSD (126)

Alias:
CD152
Country of Origin:
USA
Applications:
The Human CTLA-4 endotoxin-free recombinant protein can be used in cell culture, as an CTLA-4 ELISA Standard, and as a Western Blot Control.
None at this time

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