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Ferret IL-22 Recombinant Protein
- Catalog Number:
- RP1845FT
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Mustela putorius furo (domestic ferret)
- Ferret IL-22 (Interleukin-22) (catalog RP1845FT) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~16.9 kDa, 148 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic ferret. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-22 signaling and immune responses (including regulation of mucosal immunity, epithelial barrier function, and inflammatory pathways); typical experimental uses include cell-culture stimulation and cytokine assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | EAVPIGSHCR LANSDFEQPY ITNRTFMLAG EASLADNNTD VRLIGDTLFH GVNKEDHCYL MKEVLNFTLE EVLLPQSHRF QPYMQEVESF LTKLSNRLSQ CHIDSDDQHI QRNVQNLKDT VKKLGEDGEI KAIGELNLLF IALRDACI (148) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 16.9 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Ferret IL-22 (Interleukin-22) is a member of the IL-10 cytokine family that plays a key role in mucosal immunity and epithelial barrier protection in ferrets (Mustela putorius furo). IL-22 is produced primarily by activated CD4⁺ T cells, including Th17- and Th22-like populations, as well as by innate lymphoid cells (ILC3s) in response to microbial infection and inflammatory stimulation. It signals through the IL-22 receptor complex (IL-22R1 and IL-10R2), which is expressed mainly on epithelial and stromal cells, activating downstream JAK/STAT pathways-particularly STAT3-to induce antimicrobial peptide production, enhance chemokine expression, promote epithelial cell proliferation, and support tissue repair. In healthy ferrets, basal IL-22 expression is generally low but increases during bacterial, viral, and fungal infections, especially at mucosal surfaces of the respiratory and gastrointestinal tracts. In biomedical research, ferret IL-22 is particularly relevant in respiratory disease models such as influenza and SARS-CoV-2, where it contributes to epithelial defense and tissue regeneration while influencing inflammatory responses. Characterization of IL-22 in ferrets provides insight into mucosal immune regulation, host-pathogen interactions, and the balance between protective immunity and immunopathology in a widely used model of human respiratory infection.
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