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Feline CCL7 Recombinant Protein
- Catalog Number:
- RP1854F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Acinonyx jubatus (cheetah), Felis catus (domestic cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Panthera pardus (leopard), Panthera tigris altaica (Amur tiger), Puma concolor (puma)
- Feline CCL7 (MCP-3, Monocyte Chemoattractant Protein-3) (catalog RP1854F) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~9.0 kDa, 76 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat, cheetah, Canada lynx, Spanish lynx, leopard, Amur tiger, and puma. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL7/MCP-3 signaling and immune responses (including recruitment and activation of monocytes, lymphocytes, and other leukocytes during inflammatory processes); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QPEGINSPTT CCYRFTVRKI PIQKLKSYRR ITSSYCPREA VIFKTKQAKE LCADPKQKWV QDFMEYLDKK TQTSKL (76) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 9.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline CCL7 (C-C motif chemokine ligand 7, also known as MCP-3 - monocyte chemoattractant protein-3) is a proinflammatory chemokine that regulates leukocyte recruitment and inflammatory responses in cats (Felis catus). CCL7 is a member of the CC chemokine family, which includes related chemokines such as CCL2 (MCP-1), CCL8 (MCP-2), and CCL13 (MCP-4) that function in monocyte and leukocyte trafficking during immune activation. In cats, CCL7 is produced by macrophages, fibroblasts, endothelial cells, epithelial cells, and other immune cells in response to infection, inflammatory cytokines, or tissue injury. CCL7 exerts its biological effects through interaction with several chemokine receptors, including CCR1, CCR2, and CCR3, promoting chemotaxis and activation of monocytes, macrophages, dendritic cells, T lymphocytes, and eosinophils at sites of inflammation. In feline health, CCL7 contributes to immune responses against viral and bacterial infections and plays roles in inflammatory and immune-mediated diseases by coordinating recruitment of immune cells to affected tissues. Because chemokine-driven leukocyte migration is critical for host defense and inflammatory regulation, feline CCL7 is studied in veterinary immunology, infectious disease research, and inflammatory disease models, helping to improve understanding of chemokine signaling and immune cell trafficking in cats.
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