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Rabbit sCTLA-4 (Yeast-derived Recombinant Protein) - 500 ug (5 x 100 ug vials)

RP1858U-500
$3300.00
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Bulk quantities of proteins are available. Please contact us for bulk pricing.

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses. It is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Alternatively spliced mRNA generates a soluble form, called sCTLA-4. Whereas low levels of sCTLA-4 are detected in normal human serum, increased/high serum levels are observed in several autoimmune diseases.


Alternate Names - CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4​

sCTLA-4 Homology Across Species
Oryctolagus cuniculus (rabbit) sCTLA-4- 100%
More… https://blast.ncbi.nlm.nih.gov

Catalog No.:
RP1858U-500
Quantity:
500 ug (5 x 100 ug vials)
Source:
The Rabbit sCTLA-4 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Rabbit sCTLA-4 recombinant protein has a predicted molecular weight of 13.5 kDa.
Protein Sequence:

LHVSQPAVVL ASSRGVASFV CEYASSHKAT EVRVTVLRQA NSQMTEVCAM TYTVENELTF IDDSTCTGIS HGNKVNLTIQ GLSAMDTGLY ICKVELMYPP PYYVGMGNGT QIYVIEPEPC PDSD (124)

Alias:
CD152
Country of Origin:
USA
Applications:
The Rabbit sCTLA-4 endotoxin-free recombinant protein can be used in cell culture, as an CTLA-4 ELISA Standard, and as a Western Blot Control.
None at this time

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