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Ovine CXCL1 (GRO alpha) Recombinant Protein
- Catalog Number:
- RP1870V
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Ovis aries (sheep)
- Ovine CXCL1 (GRO-α, Growth-Regulated Oncogene alpha) (catalog RP1870V) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.9 kDa, 73 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to sheep. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL1/GRO-α signaling and immune responses (including recruitment and activation of neutrophils during inflammatory processes); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | APVVNELRCQ CLQTVQGIHL KNMQSVKVTP PGPHCGQTEV IATLKTGQEV CLNPAAPMVK KIIDKMLNQA SSN (73) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 7.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Ovine CXCL1 (C-X-C motif chemokine ligand 1, also known as GRO-α - growth-regulated oncogene alpha) is a proinflammatory chemokine belonging to the CXC chemokine family, which includes related chemokines such as CXCL2, CXCL3, and CXCL8 (IL-8) that regulate neutrophil recruitment during inflammatory responses. In sheep (Ovis aries), CXCL1 is produced by macrophages, epithelial cells, endothelial cells, and fibroblasts in response to infection, inflammatory cytokines, or tissue injury. CXCL1 primarily signals through the chemokine receptor CXCR2, promoting chemotaxis, activation, and migration of neutrophils and other innate immune cells to sites of infection or inflammation. In ovine health, CXCL1 plays an important role in innate immune defense, particularly during bacterial infections of the respiratory tract and mammary gland, where neutrophil recruitment is critical for pathogen clearance. CXCL1-mediated inflammation is also relevant in conditions such as ovine mastitis and respiratory disease, where coordinated neutrophil responses help control infection. Because neutrophil-driven immune responses are essential for protection against bacterial pathogens in sheep, ovine CXCL1 is studied in veterinary immunology, mastitis research, and host-pathogen interaction studies to better understand inflammatory signaling and immune defense mechanisms in small ruminants.
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