Atlantic Salmon (Salmo salar) CCL28 (C-C motif chemokine ligand 28, also referred to as a mucosa-associated epithelial chemokine–like molecule in teleost fish) is a chemokine involved in regulation of mucosal immune responses and leukocyte recruitment in fish. Similar to mammalian CCL28, salmon CCL28-like signaling is associated with immune cell trafficking to mucosal tissues, helping coordinate immune defense at barrier surfaces. In Atlantic salmon, CCL28 expression is primarily detected in mucosal and epithelial tissues, including the gills, skin, and intestinal tract, which are key sites of pathogen entry in aquatic environments. The chemokine contributes to recruitment of lymphocytes, macrophages, and other immune cells to these tissues following pathogen exposure or inflammatory stimulation. Atlantic salmon CCL28-like activity is particularly relevant during infections caused by bacterial pathogens such as Aeromonas salmonicida and Vibrio species, as well as viral diseases like infectious salmon anemia virus (ISAV) and salmonid alphavirus, where mucosal immune responses are critical for early pathogen control. Proper regulation of CCL28-mediated immune cell trafficking supports pathogen clearance and maintenance of mucosal barrier immunity, while dysregulation may contribute to inflammatory tissue damage. As mucosal immunity is a major focus in aquaculture disease prevention, characterization of Atlantic salmon CCL28 supports research into host–pathogen interactions, mucosal vaccine development, and immune regulation in teleost fish, contributing to improved health management in salmon aquaculture.