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Rat IL-6 Recombinant Protein
- Catalog Number:
- RP1879R
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Rattus norvegicus (Norway rat)
- Rat IL-6 (Interleukin-6) (catalog RP1879R) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~21.7 kDa, 187 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to Norway rat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-6 signaling and immune responses (including regulation of inflammation, acute-phase responses, and cytokine-mediated immune pathways); typical experimental uses include cell-culture stimulation and cytokine assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | FPTSQVRRGD FTEDTTHNRP VYTTSQVGGL ITYVLREILE MRKELCNGNS DCMNSDDALS ENNLKLPEIQ RNDGCFQTGY NQEICLLKIC SGLLEFRFYL EFVKNNLQDN KKDKARVIQS NTETLVHIFK QEIKDSYKIV LPTPTSNALL MEKLESQKEW LRTKTIQLIL KALEEFLKVT MRSTRQT (187) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 21.7 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Rat Interleukin-6 (IL-6) is a multifunctional pro-inflammatory cytokine and a central member of the IL-6 cytokine family-including IL-6, IL-11, IL-27, IL-31, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and cardiotrophin-like cytokine factor 1 (CLCF1)-which signal through receptor complexes containing the shared gp130 subunit to activate JAK/STAT and MAPK pathways. In rats (Rattus norvegicus), IL-6 is produced by macrophages, monocytes, endothelial cells, adipocytes, and other cell types in response to infection, tissue injury, metabolic stress, and immune stimulation, where it regulates acute-phase protein production, fever, leukocyte recruitment, and B- and T-cell differentiation. Rat IL-6 plays a critical role in widely used experimental models of sepsis, arthritis, neuropathic pain, cardiovascular disease, stroke, metabolic syndrome, and cancer, with elevated IL-6 levels correlating with inflammation severity and tissue damage. IL-6 is also a key mediator in models of neuroinflammation and traumatic brain injury, supporting investigation into cytokine-driven central nervous system pathology. As both a biomarker and therapeutic target, rat IL-6 is extensively utilized in preclinical pharmacology, toxicology, and immunology research to evaluate anti-inflammatory agents, biologics targeting the IL-6/IL-6R pathway, and novel immunomodulatory strategies, reinforcing its importance in translational biomedical studies.
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