Hamster CCL16 (C-C motif chemokine ligand 16), also known as liver-expressed chemokine (LEC) or HCC-4, is a member of the CC chemokine family involved in leukocyte recruitment and regulation of inflammatory responses in hamsters (e.g., Mesocricetus auratus or Phodopus spp.). CCL16 is primarily expressed in the liver and is produced by hepatocytes, monocytes, macrophages, and certain epithelial and stromal cells, particularly following inflammatory stimulation. It functions mainly through chemokine receptors such as CCR1, CCR2, and CCR5 to promote chemotaxis and activation of monocytes, lymphocytes, and other immune effector cells at sites of infection or tissue injury. In healthy hamsters, basal circulating CCL16 levels are expected to be low to moderate, contributing to immune surveillance and hepatic immune homeostasis; however, expression may increase during viral or bacterial infection, hepatic injury, systemic inflammation, or experimental immune challenge. In biomedical research, hamster CCL16 is of particular interest in infectious disease models—including SARS-CoV-2 and other viral pathogens—as well as in studies of liver pathology, inflammatory responses, and immune cell trafficking. Characterization of hamster CCL16 provides valuable insight into chemokine-mediated regulation of innate and adaptive immune responses in translational disease models.