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Feline IL-18 Recombinant Protein
- Catalog Number:
- RP1895F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Prionailurus bengalensis (leopard cat), Puma concolor (puma), Puma yagouaroundi (jaguarundi)
- Feline IL-18 (Interleukin-18) (catalog RP1895F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.2 kDa, 157 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat, jaguarundi, leopard cat, puma, Canada lynx, and Spanish lynx. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-18 signaling and immune responses (including induction of IFN-γ production, regulation of innate and adaptive immunity, and inflammatory pathways); typical experimental uses include cell-culture stimulation and cytokine assays, signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | YFGKLEHKLS ILRNLNDQVL FINQGDQPVF EDMPDSDCTD NAPRTEFIIY MYKDSLTRGL AVTISVNYKT MSTLSCENKI ISFKEMSPPE SINDEGNDII FFQRSVPGHD DKIQFESSLY KGYFLACEKE KDLFKLILKK KDENGDKSIM FTVQNKN (157) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline IL-18 (Interleukin-18) is a pro-inflammatory cytokine belonging to the IL-1 family that plays a key role in innate and adaptive immune responses in cats (Felis catus). IL-18 is produced primarily by monocytes, macrophages, dendritic cells, and epithelial cells as an inactive precursor that requires cleavage by caspase-1 following inflammasome activation to become biologically active. Once released, IL-18 promotes production of interferon-γ (IFN-γ) by T cells and natural killer (NK) cells, thereby enhancing Th1-type immune responses and cell-mediated immunity. In healthy cats, basal IL-18 expression is generally low, but levels increase during infection, inflammatory stimulation, and immune activation. Elevated IL-18 has been implicated in feline infectious peritonitis (FIP), feline immunodeficiency virus (FIV) infection, chronic inflammatory conditions, and certain immune-mediated diseases. In veterinary and comparative medicine research, feline IL-18 serves as a biomarker of inflammasome activation and Th1-mediated immune responses, providing insight into host-pathogen interactions, inflammatory disease pathogenesis, and immune regulation in feline health.
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