Rabbit Interleukin-36 Alpha (IL-36α) is a proinflammatory cytokine that plays an important role in regulating immune responses and inflammatory signaling in rabbits (Oryctolagus cuniculus). IL-36α is a member of the IL-1 cytokine family and is produced primarily by epithelial cells, keratinocytes, and immune cells in response to infection, tissue damage, or inflammatory stimuli. Rabbit IL-36α binds to the IL-36 receptor (IL-36R, also known as IL1RL2) together with the IL-1 receptor accessory protein (IL-1RAcP), activating intracellular signaling pathways such as NF-κB and MAPK that promote expression of inflammatory mediators and recruitment of immune cells. Through these pathways, IL-36α contributes to activation of dendritic cells, macrophages, and T lymphocytes and helps coordinate communication between epithelial tissues and the immune system during inflammatory responses. In cell culture, recombinant rabbit IL-36α is commonly used to stimulate inflammatory signaling in epithelial and immune cells, induce production of cytokines and chemokines, and study IL-36–mediated immune activation and epithelial–immune cell interactions in vitro. Rabbit IL-36α is also relevant in translational research, as rabbit models are frequently used to investigate inflammatory skin diseases and wound healing; for example, rabbit skin inflammation models help researchers study IL-36–driven inflammatory pathways that are relevant to human conditions such as psoriasis and other epithelial inflammatory disorders.