Rabbit IL-36 alpha (Yeast-derived Recombinant Protein) - 500 ug (5 x 100 ug vials)

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Interleukin 36, or IL-36, is a group of cytokines in the IL-1 family with pro-inflammatory effects. There are four members of the IL-36 family which bind to the IL-36 receptor (IL1RL2/IL-1Rrp2/IL-36 receptor dimer) with varying affinities. IL36A, IL36B, and IL36G are IL-36 receptor agonists. IL36RA is an IL-36 receptor antagonist, inhibiting IL-36R signaling. The agonists are known to activate NF-κB and mitogen-activated protein kinases to induce various proinflammatory mediators. Binding of the IL-36R agonists to IL-1Rp2 recruits IL-1RAcP, activating the signaling pathway. IL-36Ra binds to IL-36R, preventing the recruitment of IL-1RAcP. IL-36 has been found to activate T cell proliferation and release of IL-2. Due to their predominant expression in epithelial tissues, IL-36 cytokines are believed to play a significant role in the pathogenesis of skin diseases, especially that of psoriasis. IL-36 has also been linked to psoriatic arthritis, systemic lupus erythematosus, inflammatory bowel disease, ulcerative colitis, Crohn's disease, and Sjögren's syndrome. IL-36 is expressed by many cells types, most predominately keratinocytes, respiratory epithelium, various nervous tissue, and monocytes.

Alternate Names - IL-36 alpha, IL-36A, FIL1; FIL1E; IL1F6; IL-1F6; IL1(EPSILON); FIL1(EPSILON)

Homology Across Species
Oryctolagus cuniculus (rabbit) IL-36α- 100%
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Catalog No.:
500 ug (5 x 100 ug vials)
The Rabbit IL-36 alpha recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
The Rabbit IL-36 alpha recombinant protein has a predicted molecular weight of 18.3 kDa.
Protein Sequence:


Country of Origin:
The Rabbit IL-36 alpha endotoxin-free recombinant protein can be used in cell culture, as an IL-36 alpha ELISA Standard, and as a Western Blot Control.
None at this time

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