Bovine CCL8 (MCP-2) Recombinant Protein

Catalog Number:: RP1903B
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle)

Bovine CCL8 (MCP-2, Monocyte Chemoattractant Protein-2) (catalog RP1903B) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.6 kDa, 76 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, zebu, and wild yak. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL8/MCP-2 signaling and immune responses (including recruitment and activation of monocytes, lymphocytes, and other leukocytes during inflammatory processes); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	QPDSVSTPIT CCFSVINGKI PFKKLDSYTR ITNSQCPQEA VIFKTKADRD VCADPKQKWV QTSIRLLDQK SRTPKP (76)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	8.6 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Bovine CCL8 (C-C motif chemokine ligand 8, also known as MCP-2 - Monocyte Chemoattractant Protein-2) is a proinflammatory chemokine that regulates leukocyte recruitment and inflammatory responses in cattle (Bos taurus). CCL8 belongs to the CC chemokine family, which includes related chemokines such as CCL2 (MCP-1), CCL7 (MCP-3), and CCL13 (MCP-4) that coordinate monocyte and leukocyte trafficking during immune activation. In cattle, CCL8 is produced by macrophages, fibroblasts, endothelial cells, epithelial cells, and other immune cells in response to infection, inflammatory cytokines, or tissue injury. CCL8 exerts its biological effects through interaction with chemokine receptors including CCR1, CCR2, CCR3, and CCR5, promoting chemotaxis and activation of monocytes, macrophages, dendritic cells, T lymphocytes, and eosinophils at sites of infection or inflammation. In bovine health, CCL8 contributes to immune responses against bacterial and viral pathogens, including those involved in mastitis, bovine respiratory disease complex, and other inflammatory conditions, where recruitment of immune cells is essential for pathogen clearance. Because chemokine-mediated leukocyte trafficking is critical for effective host defense, bovine CCL8 is studied in veterinary immunology, infectious disease research, and host-pathogen interaction studies, helping to improve understanding of immune regulation and disease resistance in cattle.

Choose a size

Please choose a size to see price

RELATED MEDIA