Rabbit TWEAK (TNF-like Weak Inducer of Apoptosis, also known as TNFSF12) is a cytokine belonging to the tumor necrosis factor (TNF) superfamily, which includes related ligands such as TNF-α, Fas ligand (FasL), CD40 ligand (CD40L), TRAIL, and RANKL that regulate immune signaling, apoptosis, and tissue remodeling. In rabbits (Oryctolagus cuniculus), TWEAK is produced primarily by immune cells such as macrophages, monocytes, dendritic cells, and T lymphocytes, and can also be expressed by endothelial cells and other tissue cells during inflammation or tissue injury. TWEAK exerts its biological effects mainly through binding to its receptor Fn14 (fibroblast growth factor–inducible 14, TNFRSF12A), activating intracellular signaling pathways including NF-κB and MAPK, which regulate cell survival, proliferation, apoptosis, cytokine production, and tissue remodeling. In rabbits, the TWEAK–Fn14 signaling axis is involved in inflammatory responses, immune regulation, and tissue repair following injury or infection. Because rabbits are widely used as experimental models for cardiovascular disease, immunology, and inflammatory research, characterization of rabbit TWEAK supports studies of TNF superfamily signaling, cytokine-mediated inflammation, and mechanisms of tissue injury and regeneration relevant to both veterinary and human biomedical research.