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Rabbit TWEAK (TNFSF12) (Yeast-derived Recombinant Protein) - 25 micrograms

RP1960U-025
$300.00
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Bulk quantities of proteins are available. Please contact us for bulk pricing.

Tumor necrosis factor ligand superfamily member 12 (TNFSF12) also known as TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor ligand (TNF) ligand family. Nineteen cytokines have been identified as part of the TNF family on the basis of sequence, functional, and structural similarities. Family members include TNF beta (TNFSF1), TNF alpha (TNFSF2), Lymphotoxin beta (TNFSF3), OX40 Ligand (TNFSF4), CD40 Ligand (TNFSF5), Fas Ligand (TNFSF6), CD27 Ligand (TNFSF7), CD30 Ligand (TNFSF8), 4-1BB Ligand (TNFSF9), TRAIL (TNFSF10), TRANCE/RANKL (TNFSF11), TWEAK (TNFSF12), APRIL(TNFSF13), BAFF (TNFSF13B), LIGHT (TNFSF14), TL1A/VEGI (TNFSF15), and GITR Ligand (TNFSF18). TWEAK has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. TWEAK is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.

Alternate Names - TNFSF12, APO3L, DR3LG, TWEAK, TNLG4A, tumor necrosis factor superfamily member 12, TNF superfamily member 12

Homology Across Species
Oryctolagus cuniculus (rabbit) TWEAK - 100%
Chinchilla lanigera (long-tailed chinchilla) TWEAK – 98%
Lemur catta (Ring-tailed lemur) TWEAK – 97%
Galeopterus variegatus (Sunda flying lemur) TWEAK – 97%
More - https://blast.ncbi.nlm.nih.gov/

Catalog No.:
RP1960U-025
Quantity:
25 ug
Source:
Rabbit TWEAK (TNFSF12) was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
Rabbit TWEAK has a predicted molecular weight of 15.7 kDa.
Protein Sequence:

AAHYEVHPRP GQDGAQAGVD GTVSGWEEAK INSSNPLRYD RQIGKFIVTR AGLYYLYCQV HFDEGKAVYL KLDLLVDEVL ALRCLEEFSA TAASSLGPQL RLCQVSGLLP LRPGSSLRIR TLPWAHLKAA PFLTYFGLFQ VH (142)

Alias:
TNFSF12
Country of Origin:
USA
Applications:
The Rabbit TWEAK (TNFSF12) endotoxin-free recombinant protein can be used in cell culture, as an ELISA Standard, and as a Western Blot Control.
None at this time

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