Human Interleukin-36 Gamma (IL-36γ) is a proinflammatory cytokine that plays an important role in regulating immune responses and inflammatory signaling in humans (Homo sapiens). IL-36γ is a member of the IL-1 cytokine family and is produced primarily by epithelial cells, keratinocytes, and certain immune cells in response to infection, tissue damage, or inflammatory stimuli. Human IL-36γ binds to the IL-36 receptor (IL-36R, also known as IL1RL2) together with the IL-1 receptor accessory protein (IL-1RAcP), activating intracellular signaling pathways such as NF-κB and MAPK that promote the expression of inflammatory mediators and recruitment of immune cells. Through these pathways, IL-36γ contributes to activation of dendritic cells, macrophages, and T lymphocytes and helps coordinate communication between epithelial tissues and the immune system, particularly at barrier sites such as the skin and mucosal surfaces. In humans, IL-36γ has been strongly associated with inflammatory and immune-mediated diseases, including psoriasis, inflammatory bowel disease, and other epithelial inflammatory disorders. In cell culture, recombinant human IL-36γ is commonly used to stimulate inflammatory signaling in epithelial and immune cells, induce cytokine and chemokine production, and study IL-36–mediated immune activation and epithelial–immune cell interactions in in vitro immunology and inflammation research.