Feline CCL8 (C–C motif chemokine ligand 8, also known as MCP-2 – Monocyte Chemoattractant Protein-2) is a proinflammatory chemokine that regulates leukocyte recruitment and inflammatory responses in cats (Felis catus). CCL8 belongs to the CC chemokine family, which includes related chemokines such as CCL2 (MCP-1), CCL7 (MCP-3), and CCL13 (MCP-4) that coordinate monocyte and leukocyte trafficking during immune activation. In cats, CCL8 is produced by macrophages, fibroblasts, endothelial cells, epithelial cells, and other immune cells in response to infection, inflammatory cytokines, or tissue injury. CCL8 exerts its biological effects through interaction with chemokine receptors including CCR1, CCR2, CCR3, and CCR5, promoting chemotaxis and activation of monocytes, macrophages, dendritic cells, T lymphocytes, and eosinophils at sites of infection or inflammation. In feline health, CCL8 likely contributes to immune responses against viral and bacterial pathogens, including infections such as feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV), where chemokine-mediated recruitment of immune cells helps coordinate antiviral immunity. Because chemokines play critical roles in immune cell trafficking and inflammatory regulation, feline CCL8 is studied in veterinary immunology, infectious disease research, and inflammatory disease models to better understand immune responses and disease mechanisms in cats.