Mouse CXCL1 (C-X-C motif chemokine ligand 1), commonly known as KC (keratinocyte-derived chemokine), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL2 (MIP-2), CXCL3, and CXCL8 (IL-8) that regulate neutrophil recruitment during inflammatory responses. In mice (Mus musculus), CXCL1 is produced by macrophages, epithelial cells, endothelial cells, fibroblasts, and keratinocytes in response to infection, inflammatory cytokines, or tissue injury. CXCL1 primarily signals through the chemokine receptor CXCR2, promoting chemotaxis, activation, and migration of neutrophils and other innate immune cells to sites of infection or inflammation. In murine physiology, CXCL1 plays a critical role in innate immune defense, particularly during bacterial infections and inflammatory responses in tissues such as the lung, skin, and gastrointestinal tract. Mouse CXCL1 has been extensively studied in experimental animal models of inflammatory disease, including lipopolysaccharide (LPS)-induced acute lung injury, where CXCL1-mediated neutrophil recruitment drives pulmonary inflammation and tissue damage. Because mice are widely used as genetic and experimental models for immunology and inflammatory diseases, mouse CXCL1 has been central to understanding neutrophil trafficking, chemokine signaling pathways, and mechanisms of acute and chronic inflammation relevant to human disease.