Mink Interleukin-8 (IL-8), also known as CXCL8, is a pro-inflammatory chemokine that plays a central role in innate immune responses in mink (Neovison vison) by mediating neutrophil chemotaxis, activation, and migration to sites of infection or tissue injury. Produced by macrophages, epithelial cells, and endothelial cells in response to viral, bacterial, and inflammatory stimuli, mink IL-8 signals primarily through CXCR1 and CXCR2 receptors to promote rapid recruitment of neutrophils and amplification of local inflammatory responses. IL-8 is particularly relevant in mink health due to its involvement in diseases such as Aleutian disease virus (ADV) infection, mink viral enteritis, bacterial pneumonia, and SARS-CoV-2 infection, where dysregulated inflammatory and chemokine responses can contribute to tissue damage and disease severity. Because mink have served as important natural and experimental models for SARS-CoV-2 transmission, influenza, and immune complex–mediated diseases such as Aleutian disease, characterization of IL-8 is critical for understanding neutrophil-driven pathology, cytokine and chemokine cascades, and host responses to vaccination or antiviral interventions. As both a biomarker and mediator of inflammation, mink IL-8 supports translational research in viral pathogenesis, immune dysregulation, and comparative immunology relevant to both animal health and human infectious disease studies.