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Bovine Prolactin Receptor Recombinant Protein
- Catalog Number:
- RP2077B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos taurus (cattle)
- Bovine PRLR (Prolactin Receptor) (catalog RP2077B) is a yeast-derived protein supplied lyophilized without carrier protein in 10% trehalose; it contains no affinity tags, is naturally endotoxin-free, and should be reconstituted in sterile PBS with at least 0.1% carrier protein. The protein is ~24.8 kDa, 213 amino acids in length (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle. It is stable for up to twelve months at -20 °C from receipt, with working aliquots (with carrier protein) stable for ~3 months; avoid repeated freeze/thaw cycles. The product is manufactured in the USA. It is commonly used to study prolactin receptor signaling and endocrine regulation, including hormone binding, receptor activation, and downstream signaling pathways; typical applications include receptor-ligand interaction studies, cell-based assays, hormone signaling research, ELISA and neutralization assays, flow cytometry and Western blot controls, and antibody development or validation. Kingfisher Biotech products are supplied for research applications only and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QSPPEKPKLV KCRSPGKETF TCWWEPGADG GLPTNYTLTY HKEGETLIHE CPDYKTGGPN SCYFSKKHTS IWKMYVITVN AINQMGISSS DPLYVHVTYI VEPEPPANLT LELKHPEDRK PYLWIKWSPP TMTDVKSGWF IIQYEIRLKP EKATDWETHF TLKQTQLKIF NLYPGQKYLV QIRCKPDHGY WSEWSPESSI QIPNDFPVKD TSM (213) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 24.8kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Prolactin Receptor (PRLR) is a transmembrane receptor belonging to the class I cytokine receptor family, which also includes receptors for growth hormone (GHR), erythropoietin (EPOR), and several interleukins that signal through related intracellular pathways. In cattle (Bos taurus), PRLR binds the hormone prolactin (PRL) and activates intracellular signaling cascades, primarily the JAK2/STAT5 pathway, as well as MAPK and PI3K/AKT pathways, leading to regulation of genes involved in cell growth, differentiation, and metabolic activity. The bovine prolactin receptor is expressed in multiple tissues including the mammary gland, ovary, uterus, liver, adipose tissue, and immune cells, where it mediates the diverse physiological effects of prolactin. PRLR signaling plays a particularly important role in mammary gland development, lactogenesis, and maintenance of milk production, making it critical for dairy physiology and productivity. In addition to the membrane-bound receptor, a soluble form of bovine PRLR (sPRLR) has been described, which can arise through alternative splicing or proteolytic cleavage of the receptor extracellular domain. This soluble receptor can bind circulating prolactin and may act as a regulatory modulator of prolactin signaling, influencing hormone availability and receptor-mediated responses. Because prolactin signaling is essential for lactation performance, reproductive physiology, and metabolic regulation, bovine PRLR and its soluble form are studied in research on dairy production, endocrine regulation, and genetic traits associated with milk yield and reproductive health in cattle.
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