Human CCL8 (C–C motif chemokine ligand 8, also known as MCP-2 – Monocyte Chemoattractant Protein-2) is a proinflammatory chemokine that regulates leukocyte recruitment and inflammatory responses in humans (Homo sapiens). CCL8 is a member of the CC chemokine family, which includes related chemokines such as CCL2 (MCP-1), CCL7 (MCP-3), and CCL13 (MCP-4) that coordinate monocyte and leukocyte trafficking during immune activation. In humans, CCL8 is produced by macrophages, fibroblasts, endothelial cells, epithelial cells, and other immune cells in response to infection, inflammatory cytokines, or tissue injury. CCL8 exerts its biological effects through interaction with chemokine receptors including CCR1, CCR2, CCR3, and CCR5, promoting chemotaxis and activation of monocytes, macrophages, dendritic cells, T lymphocytes, eosinophils, and basophils at sites of inflammation. Through these actions, CCL8 contributes to host defense against viral, bacterial, and parasitic pathogens and helps coordinate innate and adaptive immune responses. Dysregulated CCL8 expression has also been associated with chronic inflammatory diseases, allergic disorders, and cancer, where it can influence immune cell infiltration and tumor microenvironment signaling. Because of its central role in chemokine-mediated leukocyte trafficking and immune regulation, human CCL8 is widely studied in immunology, infectious disease, cancer biology, and inflammatory disease research.