Hamster CCL28 (C-C motif chemokine ligand 28, also known as MEC – mucosae-associated epithelial chemokine) is a mucosal chemokine that plays an important role in immune cell trafficking and mucosal immunity in hamsters (commonly Mesocricetus auratus and Phodopus spp.). CCL28 signals primarily through the CCR10 receptor and, to a lesser extent, CCR3, promoting chemotaxis of IgA-secreting plasma cells, memory T cells, and certain dendritic cell populations to mucosal tissues. In hamsters, CCL28 is predominantly produced by epithelial cells in mucosal surfaces, including the respiratory tract, gastrointestinal tract, and salivary and mammary glands, where it helps maintain mucosal immune protection by directing antibody-producing cells to barrier tissues. CCL28-mediated recruitment of IgA-producing plasma cells is particularly important for secretory IgA responses, which provide frontline defense against pathogens at mucosal surfaces. In hamster research, CCL28 may play roles in respiratory viral infection models, including SARS-CoV-2 and other respiratory pathogens, where mucosal immune responses are critical for viral control and tissue protection. Dysregulated expression of CCL28 could influence mucosal inflammation or immune imbalance. Because hamsters are widely used as translational models for respiratory viral infections and mucosal immunology, characterization of hamster CCL28 supports studies of chemokine-mediated immune cell trafficking, mucosal antibody responses, and host–pathogen interactions relevant to human infectious disease and vaccine development.