Guinea Pig CCL20 (C-C motif chemokine ligand 20, also known as MIP-3α, macrophage inflammatory protein-3 alpha, or LARC – liver and activation-regulated chemokine) is a pro-inflammatory chemokine involved in mucosal immune responses and leukocyte recruitment in guinea pigs (Cavia porcellus). CCL20 signals primarily through the CCR6 receptor, directing chemotaxis of immune cells such as immature dendritic cells, memory T cells, and certain B cell populations to sites of epithelial infection or inflammation. In guinea pig health and research, CCL20 is particularly relevant in respiratory and mucosal infection models, including tuberculosis (Mycobacterium tuberculosis), where epithelial and immune cells produce CCL20 to recruit antigen-presenting cells and lymphocytes to infected lung tissue and granulomatous lesions. This chemokine contributes to coordination of innate and adaptive immune responses at mucosal surfaces, helping to initiate protective immunity but also potentially contributing to inflammatory pathology if excessively expressed. Because guinea pigs are widely used as translational models for tuberculosis, respiratory infections, and mucosal immunology, characterization of guinea pig CCL20 supports studies of chemokine-mediated immune cell trafficking, host–pathogen interactions, and inflammatory mechanisms relevant to human infectious and inflammatory diseases.