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Bovine CXCL7 Recombinant Protein
- Catalog Number:
- RP2107B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos taurus (cattle)
- Bovine CXCL7 (C-X-C Motif Chemokine Ligand 7) (catalog RP2107B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it contains no affinity tags, is naturally endotoxin-free, and should be reconstituted in sterile PBS with at least 0.1% carrier protein. The protein is ~8.8 kDa, 80 amino acids in length (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle and American buffalo. It is stable for up to twelve months at -20 °C from receipt, with working aliquots (with carrier protein) stable for ~3 months; avoid repeated freeze/thaw cycles. The product is manufactured in the USA. It is commonly used to study chemokine-mediated immune responses, particularly neutrophil activation, platelet-derived signaling, and inflammation; typical applications include chemotaxis and cell migration assays, immune cell activation studies, cytokine signaling research, ELISA and neutralization assays, flow cytometry and Western blot controls, and antibody development or validation. Kingfisher Biotech products are supplied for research applications only and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | KLSSKERFLH IELRCLCVKT ISGIPSSNIQ SLEVNRAGPH CNKVEVIAEL KNGKKICLNP EGPRIKKIVQ KILEDGGLAA (80) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.8kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CXCL7 (C-X-C motif chemokine ligand 7), also known as NAP-2 (neutrophil-activating peptide 2) or PPBP (pro-platelet basic protein), is a platelet-derived chemokine belonging to the ELR⁺ CXC chemokine family, which also includes CXCL1, CXCL2, CXCL3, and CXCL5 that regulate neutrophil recruitment during inflammatory responses. In cattle (Bos taurus), CXCL7 is produced primarily by platelets and megakaryocytes and is released upon platelet activation during vascular injury, inflammation, or infection. CXCL7 signals mainly through the chemokine receptor CXCR2, expressed on neutrophils and other innate immune cells, promoting neutrophil chemotaxis, activation, and migration to sites of tissue damage or infection. In bovine health, CXCL7 contributes to the interaction between the coagulation system and immune responses, particularly in inflammatory conditions affecting tissues such as the mammary gland and respiratory tract, where platelet activation and neutrophil recruitment play roles in host defense during diseases such as mastitis and respiratory infections. Because platelet-derived chemokines influence both hemostasis and inflammatory signaling, bovine CXCL7 is studied in veterinary immunology, inflammation research, and host-pathogen interaction studies to better understand platelet-mediated immune regulation and neutrophil-driven inflammatory responses in cattle.
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