Bovine CXCL7 (C-X-C motif chemokine ligand 7), also known as NAP-2 (neutrophil-activating peptide 2) or PPBP (pro-platelet basic protein), is a platelet-derived chemokine belonging to the ELR⁺ CXC chemokine family, which also includes CXCL1, CXCL2, CXCL3, and CXCL5 that regulate neutrophil recruitment during inflammatory responses. In cattle (Bos taurus), CXCL7 is produced primarily by platelets and megakaryocytes and is released upon platelet activation during vascular injury, inflammation, or infection. CXCL7 signals mainly through the chemokine receptor CXCR2, expressed on neutrophils and other innate immune cells, promoting neutrophil chemotaxis, activation, and migration to sites of tissue damage or infection. In bovine health, CXCL7 contributes to the interaction between the coagulation system and immune responses, particularly in inflammatory conditions affecting tissues such as the mammary gland and respiratory tract, where platelet activation and neutrophil recruitment play roles in host defense during diseases such as mastitis and respiratory infections. Because platelet-derived chemokines influence both hemostasis and inflammatory signaling, bovine CXCL7 is studied in veterinary immunology, inflammation research, and host–pathogen interaction studies to better understand platelet-mediated immune regulation and neutrophil-driven inflammatory responses in cattle.