Jamaican Fruit-eating Bat (Artibeus jamaicensis) Interleukin-6 (IL-6) is a multifunctional pro-inflammatory cytokine that plays a central role in regulating immune responses, acute-phase reactions, and inflammatory signaling, likely functioning through the conserved IL-6R/gp130-mediated JAK/STAT pathway as described in other mammals, with potential species-specific regulatory adaptations. As a widely distributed Neotropical bat species frequently used in ecological and infectious disease research, characterization of IL-6 in A. jamaicensis is important for understanding how this species responds to viral, bacterial, and parasitic challenges while maintaining controlled inflammation. In animal health settings, IL-6 serves as a key biomarker of immune activation and systemic inflammation, supporting health monitoring, disease surveillance, and welfare assessment in managed colonies. In animal model research, studying Jamaican Fruit-eating Bat IL-6 enhances comparative immunology efforts by enabling analysis of cytokine signaling differences between bats and other mammals, improving insight into host-pathogen interactions, immune tolerance mechanisms, and the development of species-specific reagents necessary for accurate immune profiling and translational studies of emerging infectious diseases.