Bovine, Caprine, Ovine, Rat, and Swine CXCL14 (C-X-C motif chemokine ligand 14), also known as BRAK (breast and kidney–expressed chemokine), is a homeostatic chemokine belonging to the CXC chemokine family involved in immune surveillance, epithelial defense, and tissue homeostasis. In cattle (Bos taurus), goats (Capra hircus), sheep (Ovis aries), rats (Rattus norvegicus), and pigs (Sus scrofa), the CXCL14 protein is identical at the amino acid level, indicating strong evolutionary conservation and suggesting similar biological functions across these mammalian species. CXCL14 is widely expressed in epithelial tissues, skin, mucosal surfaces, and various organs, where it is produced by epithelial cells, fibroblasts, and other stromal cells. Unlike many inflammatory chemokines, CXCL14 is typically expressed under homeostatic conditions and contributes to recruitment of immune cells such as dendritic cells, monocytes, and natural killer (NK) cells, supporting early immune surveillance and maintenance of tissue integrity. In livestock species such as cattle, sheep, goats, and pigs, CXCL14 likely contributes to mucosal and epithelial immune defenses against environmental pathogens, including those affecting the skin, respiratory tract, and gastrointestinal tract. Because CXCL14 is involved in innate immune regulation, epithelial barrier defense, and immune cell recruitment, and is structurally identical across these species, it is relevant to comparative immunology, veterinary infectious disease research, and studies of epithelial immunity and inflammatory regulation.