Dolphin interleukin-24 (IL-24) is a member of the IL-10 cytokine family—which includes IL-10, IL-19, IL-20, IL-22, and IL-26—and is expected to function similarly to other mammalian IL-24 homologs in regulating immune responses, epithelial biology, inflammation, and tumor-related pathways through IL-20 receptor–mediated JAK/STAT signaling. In dolphin health, IL-24 and related IL-10 family cytokines likely contribute to maintaining mucosal and skin barrier integrity, modulating inflammatory responses to marine pathogens, and balancing immune activation in conditions such as dermatitis, wound healing complications, respiratory infections, and gastrointestinal inflammation commonly observed in managed and wild cetacean populations. Given increasing reports of neoplasia in dolphins, IL-24 may also have relevance in tumor surveillance and anti-tumor immune regulation, paralleling its studied roles in human cancers including melanoma, lymphoma, colorectal, lung, pancreatic, and breast cancers. As marine mammals share conserved immune architecture with other mammals while exhibiting unique adaptations to aquatic environments, dolphin IL-24 provides value both for advancing cetacean veterinary care and for comparative immunology research, offering insight into immune regulation, inflammatory disease, and cancer biology across species.