Bovine CXCL17 (C-X-C motif chemokine ligand 17), also known as DMC (dendritic cell and monocyte chemokine), is a mucosal chemokine belonging to the CXC chemokine family that plays an important role in innate immune defense and recruitment of myeloid immune cells at mucosal surfaces. In cattle (Bos taurus), CXCL17 is primarily produced by epithelial cells of mucosal tissues, including those in the respiratory tract, gastrointestinal tract, and other barrier surfaces, where it contributes to immune surveillance and early responses to microbial exposure. CXCL17 acts as a chemoattractant for monocytes, macrophages, and dendritic cells, helping recruit these cells to mucosal tissues where they participate in pathogen detection, antigen presentation, and initiation of immune responses. In bovine health, CXCL17 likely contributes to protection against respiratory and enteric pathogens, including those associated with bovine respiratory disease complex and gastrointestinal infections, by promoting immune cell accumulation and antimicrobial activity at epithelial barriers. Because mucosal immunity is critical for defense against pathogens encountered in the environment, bovine CXCL17 is studied in veterinary immunology, respiratory disease research, and host–pathogen interaction studies to better understand chemokine-mediated immune cell recruitment and barrier immunity in cattle.