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Human CCL1 Recombinant Protein
- Catalog Number:
- RP2192H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human)
- Human CCL1 (C-C Motif Chemokine Ligand 1) (catalog RP2192H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it contains no affinity tags, is naturally endotoxin-free, and should be reconstituted in sterile PBS with at least 0.1% carrier protein. The protein is ~8.5 kDa, 73 amino acids in length (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. It is stable for up to twelve months at -20 °C from receipt, with working aliquots (with carrier protein) stable for at least ~3 months; avoid repeated freeze/thaw cycles. The product is manufactured in the USA. It is commonly used to study chemokine-mediated immune responses, particularly lymphocyte recruitment, inflammation, and cytokine signaling pathways; typical applications include chemotaxis and cell migration assays, immune cell activation studies, cytokine signaling research, ELISA and neutralization assays, flow cytometry and Western blot controls, and antibody development or validation. Kingfisher Biotech products are supplied for research applications only and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | KSMQVPFSRC CFSFAEQEIP LRAILCYRNT SSICSNEGLI FKLKRGKEAC ALDTVGWVQR HRKMLRHCPS KRK (73) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.5kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CCL1 (C-C motif chemokine ligand 1), also known as I-309, is a member of the CC chemokine family that plays a role in regulating leukocyte trafficking and immune responses. CCL1 is produced primarily by activated CD4⁺ T lymphocytes, monocytes, macrophages, dendritic cells, and certain endothelial and epithelial cells in response to inflammatory cytokines and immune stimulation. It signals predominantly through the CCR8 receptor to promote chemotaxis and activation of T cells, monocytes, and regulatory T cells, contributing to the orchestration of immune responses at sites of inflammation. In healthy individuals, circulating CCL1 levels are typically low, but expression increases during infection, allergic inflammation, autoimmune disease, and tumor-associated immune responses. Elevated CCL1 has been implicated in conditions such as asthma, atopic dermatitis, inflammatory bowel disease, rheumatoid arthritis, and certain cancers, where it may contribute to chronic inflammation or immune cell recruitment within the tumor microenvironment. In clinical and translational research, human CCL1 serves as a biomarker of immune activation and Th2- or regulatory-associated responses and represents a potential therapeutic target for modulating inflammatory and immune-mediated diseases.
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