Guinea Pig CXCL11 (C-X-C motif chemokine ligand 11), also known as I-TAC (Interferon-inducible T-cell alpha chemoattractant), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL10 (IP-10) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In guinea pigs (Cavia porcellus), CXCL11 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), microbial infection, or inflammatory cytokines. CXCL11 signals primarily through the chemokine receptor CXCR3, expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. Guinea pigs are widely used as animal models for tuberculosis caused by Mycobacterium tuberculosis because they develop granulomatous lung lesions and immune responses that closely resemble human tuberculosis. In this model, CXCL11 contributes to the recruitment of CXCR3⁺ T cells to infected lung tissue, supporting Th1-type immune responses and granuloma formation. Consequently, guinea pig CXCL11 is important for studies of interferon-driven immunity, chemokine-mediated T-cell trafficking, and host–pathogen interactions in tuberculosis research.