Rabbit Leptin is a peptide hormone that plays a key role in regulating energy balance, metabolism, and endocrine function in rabbits (Oryctolagus cuniculus). Leptin is produced primarily by adipocytes in adipose tissue and circulates in the bloodstream to signal nutritional status to the central nervous system. Rabbit leptin binds to the leptin receptor (LEPR), a member of the class I cytokine receptor family, activating intracellular signaling pathways including JAK–STAT, PI3K–AKT, and MAPK that regulate appetite, energy expenditure, and metabolic homeostasis. Through these pathways, leptin helps control food intake, body weight, lipid metabolism, and glucose regulation. In rabbits, leptin is also involved in reproductive physiology, immune regulation, and developmental processes. In cell culture, recombinant rabbit leptin is commonly used to stimulate leptin receptor signaling in neuronal, adipocyte, and immune cell models to study mechanisms of metabolic regulation and hormone signaling. Rabbit leptin is also studied in animal models of obesity, metabolic syndrome, and reproductive biology, where rabbit models help researchers investigate leptin-mediated control of appetite, adipose tissue function, and metabolic disease relevant to human physiology.