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Bovine CCL26 Recombinant Protein
- Catalog Number:
- RP2226B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos grunniens (domestic yak), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo), Bubalus kerabau (carabao)
- Bovine CCL26 (C-C Motif Chemokine Ligand 26) (catalog RP2226B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it contains no affinity tags, is naturally endotoxin-free, and should be reconstituted in sterile PBS with at least 0.1% carrier protein. The protein is ~8.4 kDa, 71 amino acids in length (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, American buffalo, domestic yak, zebu, wild yak, water buffalo, and carabao. It is stable for up to twelve months at -20 °C from receipt, with working aliquots (with carrier protein) stable for ~3 months; avoid repeated freeze/thaw cycles. The product is manufactured in the USA. It is commonly used to study chemokine-mediated immune responses, particularly eosinophil recruitment, allergic inflammation, and cytokine signaling pathways; typical applications include chemotaxis and cell migration assays, immune cell activation studies, cytokine signaling research, ELISA and neutralization assays, flow cytometry and Western blot controls, and antibody development or validation. This material was generated with support from the USDA CSREES Veterinary Immune Reagent Network. Kingfisher Biotech products are supplied for research applications only and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | TRGSDVAKFC CFQYSQKTLP WKQVHSYEFT RNICSLKAVI FTTKRGRKVC AQPKEEWVQR HISKLRAQQQ L (71) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine CCL26 (C-C motif chemokine ligand 26, also known as eotaxin-3) is a chemokine involved in recruitment of eosinophils and regulation of type 2 inflammatory responses in cattle (Bos taurus). CCL26 primarily signals through the CCR3 receptor, promoting chemotaxis of eosinophils, basophils, and Th2 lymphocytes to sites of infection, allergic inflammation, or tissue injury. In cattle, CCL26 is produced by epithelial cells, macrophages, fibroblasts, and endothelial cells in response to Th2-associated cytokines such as IL-4 and IL-13, which drive eosinophil-mediated immune responses. Bovine CCL26 is particularly relevant in parasitic infections, including gastrointestinal nematodes and other helminth parasites, where eosinophil recruitment contributes to parasite defense and mucosal immune protection. This chemokine may also participate in inflammatory responses in tissues such as the respiratory and gastrointestinal tract, influencing immune cell infiltration and tissue remodeling during infection or inflammation. While CCL26-mediated eosinophil trafficking supports protective immunity against parasites, excessive or prolonged expression could contribute to inflammatory tissue damage. As a regulator of eosinophil recruitment and Th2-associated immune responses, bovine CCL26 is important for studies of host-parasite interactions, mucosal immunity, and inflammatory disease mechanisms affecting cattle health and productivity.
5 ug
Price: $170.00
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