Bovine CCL26 (C-C motif chemokine ligand 26, also known as eotaxin-3) is a chemokine involved in recruitment of eosinophils and regulation of type 2 inflammatory responses in cattle (Bos taurus). CCL26 primarily signals through the CCR3 receptor, promoting chemotaxis of eosinophils, basophils, and Th2 lymphocytes to sites of infection, allergic inflammation, or tissue injury. In cattle, CCL26 is produced by epithelial cells, macrophages, fibroblasts, and endothelial cells in response to Th2-associated cytokines such as IL-4 and IL-13, which drive eosinophil-mediated immune responses. Bovine CCL26 is particularly relevant in parasitic infections, including gastrointestinal nematodes and other helminth parasites, where eosinophil recruitment contributes to parasite defense and mucosal immune protection. This chemokine may also participate in inflammatory responses in tissues such as the respiratory and gastrointestinal tract, influencing immune cell infiltration and tissue remodeling during infection or inflammation. While CCL26-mediated eosinophil trafficking supports protective immunity against parasites, excessive or prolonged expression could contribute to inflammatory tissue damage. As a regulator of eosinophil recruitment and Th2-associated immune responses, bovine CCL26 is important for studies of host–parasite interactions, mucosal immunity, and inflammatory disease mechanisms affecting cattle health and productivity.