Ferret and Mink Platelet-Derived Growth Factor-BB (PDGF-BB) is a homodimeric growth factor composed of two PDGF-B chains that plays an important role in cell proliferation, migration, angiogenesis, and tissue repair in mustelids, including ferrets (Mustela putorius furo) and mink (Neovison vison), where the protein sequence is highly conserved and functionally identical. PDGF-BB signals primarily through platelet-derived growth factor receptor-β (PDGFR-β) and PDGFR-α/β receptor complexes, activating intracellular signaling pathways such as PI3K/AKT, MAPK, and STAT, which regulate fibroblast proliferation, smooth muscle cell growth, and extracellular matrix production. In ferrets and mink, PDGF-BB is produced by platelets, macrophages, endothelial cells, and fibroblasts and is released during tissue injury, inflammation, and wound healing. It plays important roles in vascular remodeling, dermal repair, and connective tissue regeneration, supporting recovery following injury or infection. PDGF-BB signaling may also contribute to fibrotic responses and tumor-associated stromal remodeling during chronic inflammation or neoplastic disease. Because ferrets and mink are used in comparative infectious disease and respiratory research, including models of influenza and SARS-CoV-2 infection, PDGF-BB is relevant to studies of tissue repair, inflammatory responses, and vascular changes that occur during infection and recovery.